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Personally I think there is more nutrition in one large feeder versus two smaller ones. Two smaller feeders have more skin and less meat than one larger one of the same weight. Plus, I believe I've read that more mature prey is healthier than babies. All that being said, doubling up on smaller feeders every now and then to use up a size or whatever is probably fine. Feeding a snake only pinkies its entire life is probably not.
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