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Has he recently shed or nearing a shed? What you are describing can be the onset of an URI and in that case, the sooner you can start treatment, the better.
However, just before shedding, sometimes the areas around the snake's mouth and nostrils will swell, sometimes a little, sometimes a lot and that can make them really sound like they've got an URI, especially when they are exerting themselves. If that is the case, it should clear up very soon after he sheds.
On the other hand, if he just shed, it is possible that he retained some shed on his face and that could be causing the issue too. You'll want to check both of those possibilities before you take him to the vet.
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