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As far as healthier, I would start with completely unrelated snakes. Reptiles can endure more line breeding or in breeding before you start seeing problems. They're not like mammals. However, with a number of projects, someone will produce a clutch of babies, they'll sell them, often in pairs, those will be bred together, and often sold in pairs, etc.
For the healthiest lines, I'd work towards completely unrelated pairings. That can be more complicated, especially when adding in different genes, but it's better in the long run.
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