I'm not experienced with nicotine and snakes, BUT I am experienced in nicotine and kids. I see the result of kids that are exposed to nicotine every single night in the ER. Babies whose parents smoke come in all of the time with severe asthma reactions. A lot of these parents smoke outside, but they forget to wash their hands. Just the contact with their nicotine-tainted fingers causes extreme bronchiole constriction and can result in some nasty asthma exacerbations. I always stress to these parents PLEASE wear a jacket or something when you go out to smoke. Then, leave the jacket outside, wash your hands up to your elbows for at least 30 seconds with soap and water, and wash your face and brush your teeth as well. Even those parents who use chewing tobacco get the "please wash your hands and face and brush your teeth prior to handling the baby" speech.
It stands to reason that a tiny little snake, with only one REAL lung, would experience symptoms of airway constriction if exposed to smoke or nicotine.
However, there are lots of diehard smokers whose kids have never had asthma or sore throats or frequent colds (also common for smoke-exposed kids). I'm sure they'll state vehemently that they've smoked in the same room with their snakes for xyz years and never had a negative experience. I strictly speak from my experience as an Human ER Nurse. Maybe this doesn't apply to snakes.
I would suggest that it wouldn't hurt to smoke in another room and wash your hands thoroughly before handling.
sorry this was so long. I didn't start out to be this verbose.
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