I'm not sure, she could have had a stroke, she could have some sort of nerve damage, or she could have a genetic disease. A friend of mine had rats that had a disease that caused them and all of their young to drop dead when they were a few months old, the parents lived a few months longer than the babies, though. No symptoms, the only thing she noticed was that the father was no longer really fat, then a few days later....
BTW, the disease you're thinking of is megacolon, it only affects rats that are around 3-4 weeks old. Megacolonic (is that a word?) rats can't pass feces, and die very early.
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