There's an Island about 45 minutes south of Charleston SC that is a very good vacation spot. Edisto Island SC and My wife and I spend a week there every May. The Island is very quiet with some nice beaches. Not very commercial yet they do have some nice attractions. They built a Serpentarium there a few years ago, and with my facination with snakes, I make it a point to go there a couple of times while we're in Edisto.
They have a very nice indoor exhibit, but the outside area is fantastic. Two large natural exhibits (one for venomous and the other for non-venomous) snakes, a Croc area, and another for Turtles. They also have a small ampitheater for doing snake fact shows for tourists and school groups.
The reptiles are all caught locally and are released back into the wild after the season. (open May to October). Of course my favorites are the Corn snakes, and they said this past May, they are noticing a big increase in the Okeetee Corns they're catching down in the lowcountry SC. Thought I'd post a few pictures of the exhibits. These are the new ones, I have tons more from the past 3 years.