A very humane way to kill mice without any fancy setups is to use a zip lock bag, and put some bedding inside it, put about 10 mice per ziplock back, and blow into the ziplock back to puff it up a bit and lock the bag (just have enough space in there so that they're not squished or struggling around and getting claustrophobic). Leave the bag in a dark quiet place for a few hours (one hour seems to be sufficient for me when dealing with fuzzies, but this may differ depending on the size of bag you use, etc, just check every hour or so, drowsy mice don't really mind you checking on them).
The mice will all huddle into a bundle to stay warm, and they'll breath rapidly because they're cold, expelling a lot of CO2 from respiration. The air in the bag slowly turns into 100% CO2, and they'll fall into a sleep and sooner or later get asphyxiated and die. The bedding also helps calm them, since it's a familiar scent to them, and they won't panic. The bedding also soaks up their urine, since mice seem to urinate when they die through asphyxiation. With very small mice (newborns), this method takes a long long time, since baby mice have a different type of hemoglobin that has a higher affinity to oxygen than slightly older mice.
Note: This does not work for any mouse that's mature enough to have open eyes and can run around, they'll chew their way out the bag and more importantly they'll probably panic.
Mice need atleast 60 deg F to not catch pneumonia or other nasty respiratory illness.
-Lemur 6
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