Amphibians are very sensitive when it comes to chemicals, so it would make sense that there would be materials that are reptile safe but not amphibian safe. Especially if the adhesive is completely sealed by reptile safe substances and is given plenty of time to dry/gas off harmful chemicals.
I am a fan of Drylok and have used it to seal numerous projects.
That said, snake poop is terribly difficult to remove from Drylok and grout. A smooth epoxy seal would be much, much easier to clean.
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