It should not, just keep it clean. Typically loosing the very tip is a minor injury and heals quickly, even without polysporin. (but still its a good idea to use it) It happens sometimes with incomplete sheds that get stuck around the tip and retrict blood flow. I have a 4 year old female that lost the tip of her tail as a hatchling. She has no idea shes any different and its barely noticable.