OK, so I started a breeding colony on May 7th. The 1st litter came on May 29th, all were killed. 2nd litter on June 3rd, half survived. There was a 3rd litter on June 7th and all of these survived. Good it's working, I thought. The largest adult female died on June 21st and I put in a replacement the next day. They accepted her, no fighting or anything, but there is no signs of breeding. None of the females look pregnant. Shouldn't they be more productive? Perhaps I should start over with new mice? I am discouraged and befuddled and am about to feed them off to some hungry Kings! Any thoughts or advice? :shrugs: