I'm still pretty new to snakes but I'm handling our new snake for about 15 minutes each day. I don't handle her for two days after she eats. And right now she seems to be getting ready to shed. Her colors were dull, she's hiding a lot. I was worried since I didn't see her come out at her normal time, so I really rummaged around to find her (it's a big tank) and when I finally found her she was very anxious and didn't seem to be comfortable with being held. They can't see very well when they're getting ready to shed.
So for now I'm not bothering her till after she sheds.