Not quite sure. I made a rule of holding her every day except the day after feeding. It isn't like one day they just trust you. They trust more and more, in different ways.Also, it depends on the snake. For example, when I had Xia, after a month, she didn't jump when I got her out of the cage. After about three months she wasn't jumpy when I stroked her with my finger, and didn't even turn a head, and a week or so later, I could touch her head and tail without any response. By the six month mark, I could pick her up any way I wanted and she wouldn't even flinch. I've had her about a year, and to this day, I notice different ways she becomes more and more tame.