Breeding for the first time at a year? By then, most mice are middle-aged. I had a female breed for the first time when she was 3.5 weeks old. She had 9 babies when she was 7 weeks. She went on to have 8 more litters before I retired her AT 1 year of age! Rats live longer than mice generally, and you will get many litters from one female rat. I've had over 16 litters from one female. She is now getting old and her litters are dropping off, so now she is just a pet. Its difficult to "give them a break", its easier to just keep breeding them until their production slows. Then just replace them with thier daughters. It will only take another 6 weeks before they are having babies too! And one of the best things to do, is to raise up her replacement as she is having her last few litters, so that her daughter "learns" how to take care of babies and may even help out with them whe she herself is only a month old.