Metacam is fairly new. I know some vets who swear by it and others who are only lukewarm. It doesn't always work, but when it works it seems to work really well, and we haven't seen any bad side effects from it yet. It made a couple of dogs nauseous, but then you just switch them to another drug. And yes, rimadyl can potentially cause some serious liver side effects, but so can deramax. both carprofen and deracoxib can cause severe kidney, liver and gastrointestinal problems. They are very similar drugs that work in much the same way. Dogs on these kinds of medications should always be monitored carefully. But, having said that, we have't seen any serious side effects with these. We did see a couple of dogs come in with gastric problems, but these were very old dogs who had been on rimadyl continuously for years. anyhow meg, you sound like you've done your research and are taking great care of your animals! :wavey: