There is a difference...you are pretty much getting them the same "weight" of food either way, but the fuzzies are generally too large atfirst for a snake that can eat 6 gram prey items...so until they get big enough you feed them two pinkies...
You seem to be kind of new...on the main page scroll down to the user forums, the one called "Roy Munson's Serpent Lounge" Click on it...the first thread should be called "The Munson Plan"...these are good GUIDELINES to follow. It's not set in stone...but most people on here like to use this chart to base their own feedings on......