4-6 is small for a first time litter, but I find that sometimes too big a first time litter the mother's milk doesn't cover for them all. But with my colony the later litters all the babies seem to get enough and grow fat and sassy. But as already stated, hold back babies from the largest litters. Feed off portions of those said larger litters too once they are sexable to enable the smaller amount of babies left to get more milk and thus grow up bigger. In my mind a bigger well grown mouse makes a better breeder than one that had to fight tooth and nail to grow up competing with so many siblings and usually wean at a smaller size. Something to think about...
Another point, although we have this mindset that outcrossing is always good, your mixing in new genetics that may are may not help at all! Plus the possibility of introducing a new strain of bacteria that could even kill off the strain you already have. It's just something I've run into while I've had mice. I have a colony that are said to have come from Gourmet Rodent when the Petco in Fargo had some in and I had asked where they came from. Anyhow, these white mice produce like crazy but when I put a different mouse in from somewhere else, about half the time the white mice will get sickly after a few weeks and even die off. So be very careful of introducing new mice to the colony! I started off with ONE trio of these white mice and from that trio comes my whole albino line that I keep seperate from my colored line in that I only let white mice breed to white mice and never take a mouse from my overstock where weanlings from all strains go into. Once they hit the overstock bin they are no longer considered for breeding. Cause I do cross the whites to the colored ones in an effort to get my colored strains to produce like the white ones. It's working, but the colored mice throw about half white mice. So I make the effort to keep the white strain pure but certainly allow the few colored strains to be outcrossed to my white strain for better production.
sorry, I see I got to rambling...oops... :nope: