I usually bop all my rodents. I don't like the idea of freezing a baby animal (or any animal for that matter) to death. With pinkies just flick them in the back of the head, kills them instantly. If you don't have a CO2 chamber you can bop them, it's how I break the necks, and it's how I was taught to humanely kill a mouse. It sounds horrible, but it is instant if done right. All you do is take the mouse by the base of the tail and swing it into something solid, like a cinderblock. So basically it hits its head on the block, which severs the spine from the skull. You'll know you did it right if the mouse urinates (signaling death). Another way to do it is to place a screwdriver over the back of the mouses head and pull quickly on it's tail, if done right this also severs the spine from the skull. I have noticed that I get a lot more nose bleeds with the second method, which is not fun for anyone.
Also, it takes a while for mice to really get going with their breeding. I've had mine for about four or five months now and just one of my females has started to really pump out babies. I have a 1:3 ratio right now, soon I will be increasing to 1:4 after removing a female who has not produced for me at all.