I am going to have to disagree with this kind of over-generalization.
Not all animals can be tamed by handling and/or familiarity with the handler. This doesn't mean it is because those animals are afraid or stressed, it's an instinctual survival response.
At best, a handler can become highly attuned to that animal's behaviors and learn how to intermingle successfully with it, but that doesn't equate to the animal being tamed. It's more like the handler has been trained to accomodate the animal behaviors, not the other way around.
Even so-called tamed animals sometimes react aggressively due to their primal natural instincts for unknown reasons. This doesn't mean that the animal was afraid or stressed. But it can mean that the handler was either not in tune with that animals behavioral pattern that day or it could have been an anomalous event.
I honestly believe that it can be dangerous when you over-generalize about taming animals, especially reptiles. It allows people to think that their pet snake is incapable of reacting in an aggressive manner because it has been "tamed" due to lots of handling. The truth is, no animal should ever be thought of as being tamed. That way you never lose focus of what that animals true abilities to react in a fashion which you are unprepared for.