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Stargazer gene still around?

yes, I don't know an european breeder who has an adult gazer because afaik here in europe aren't any adults, but we have MUCH carriers here and that's a fact. I know a breeder who sold them without knowing it for years in hamm and several other showes.

At some point my girls will be shifted from Pets to being breeders to testing out a certain animals, and then after they have helped me along, I am certainly not going to off them poor creatures because they are retards. I intend to care for them for the rest of their lives, as this is what I consider to be the most ethically correct thing to do. Does this make me some monster or twisted individual ? I don't think so.. Does it make me unethical? No.. I don't think I have heard anyone here ever say they are intending to create a a clutch of Stargazers to profit of the Gazer animals, I think you have come to the wrong choir to preach ethics too..

No that wouldn't make you a monster and that's not what I've said. I'm speaking of people who want a gazer because it's a gazer and not because of testing their lines. THAT is unethical; to produce/buy some in order to prove your lines isn't unethical anywise. when you keep the gazer until its end, so what, no problems from my side....why should I have any...

If customers WANT them, you know and I know that there will be someone who'll bred gazers for them, so the customers manipulate the market too. supply and demand?! Remember the scaleless corns. I don't say that this will be anyone of this board, but there's more than just cornsnakes.com and the european market is meanwhile bigger than ever before. I've never said anything about anyone and I know when I have to speak from ethic. I think you got me wrong.
 
And to TandJ... The writhing/circling/backtracking doesn't seem dizzy to you? But then again, how would you be able to tell if a snake is dizzy either way? They do not appear to get nystagmus the way mammals do.

A vestibular dog or cat can be quite calm until moved. Then they spaz because their frame of reference has been altered. The video I chose was of a recently diagnosed dog. If you go on youtube, you can find recovering vestibular dogs that instead have the head tilt/wobble and a tendency to lean and list and tremble when walking, but are not full circling/flailing anymore.
__________________

Again, have you first handed seen one of these animals? Have you hand raised these animals from hatchlings? The Stargazers do not have their eyes flicking about, they do not appear to have any visual impairments, ask the the mice they they eat *lol*.. I believe it was shown at some point that indeed the snakes ear canel and other parts have been NOT known to have been deformed, show anomalies etc, via disection, etc, of a Stargazer.. You are day late and a dollar short with your hypothisis..
 
Regardless of who is right who is ethical or what ever. I personally think that everyone that breeds corns should get there hands on a male and female stargazer to prove out there lines.

I know in the future I now plan to get my hands on a pair to test out all my males and females even though I dont have and have never had any signs of stargazing.
 
First off, "fun" is not the same as "interesting." The fact that a deleterious allele has been discovered as a result of selective breeding for pattern and color alleles is interesting. The fact that the deleterious allele existed out there in the real world of cornsnakes but is obviously under strong negative selection is interesting and stargazers, therefore, make a very clear and real example of real-time, real-life negative selection, which is why "I would take it into lab when teaching Mendelian genetics, just like I take in all the others."

I certainly would not breed for them, as I stated that if I found out I had the gene in my collection I wouldn't breed those animals anymore.

I also am not concerned enough about the existence of the allele in the captive population to maintain one just to test breed my other animals to it. I personally don't think it's worth putting my females through the stress of egg-laying for that purpose, and I personally don't want to have to euthanize entire clutches of het stargazers, since I wouldn't ever knowingly let a het stargazer out of my house. But I surely respect the positions of people who do.

Do I think someone will breed one "for me," to satisfy my market of one? Doubtful. Nor will it be necessary. The allele is out there already. People will be producing them unintentionally. I will not buy a stargazer. But when I have a little more space, I would like to give an unintentionally produced stargazer a non-breeding forever home, because I think they are interesting.

If I thought stargazers suffered, I would not keep one and would favor euthanizing all of them. But I don't think they suffer much.
 
Out of curiosity, when you test breed your animals for stargazing by breeding to a known stargazer, do you incubate the eggs, hatch them out, observe them, and then destroy the entire clutch? I understand the need to test animals in an attempt to eradicate the gene, but I just can't imagine (personally) going through that. This is probably why I will personally enjoy SK from afar.

We bought a spider ball who had a severe wobble. I had never seen this before, but watching him the first few days in his new enclosure was heart breaking. I thought for sure I would have him euthanized. But once he settled in, he got around well, ate f/t no problem, etc. We wound up giving him to a friend of ours who will enjoy him for what he is and never breed him.
 
Out of curiosity, when you test breed your animals for stargazing by breeding to a known stargazer, do you incubate the eggs, hatch them out, observe them, and then destroy the entire clutch? I understand the need to test animals in an attempt to eradicate the gene, but I just can't imagine (personally) going through that. This is probably why I will personally enjoy SK from afar.


Observing the young is the only way of diagnosing the problem, so yes that is what will need to be done. Sad, but true. To those who say they would keep all their stagazers, if they produce them, remember that if you produce ONE homo stargazer in a clutch, you need to keep that one. Fine. But the rest of the clutch are 66% poss het stargazer, so what do you do with them? Plus, with the breeding required to produce ONE stargazer in a clutch, in a clutch of 16 eggs, the odds are you will actually produce FOUR homo stargazers.

A very noble thought, but gets a bit practically difficult.
 
I do not believe it is a vestibular disease or that the gazer's are dizzy. Dr. Connie Hurley sent one of her gazer's for pathological exam and nothing was found. So whatever is wrong with these animals is not visible under pathological exam. This would suggest a metabolic abnormality.

I have a gazer female and I agree with Tim that she acts more like someone with a movement disorder but not really Parkinson's disease. I really do not think she is suffering. If she was I don't believe she would be as good an eater as she is. She produced a beautiful clutch for me last year and is set to live out her life here as a pet. Her offspring were all het gazer's and proved to a greater than 99% chance that my male sunkissed does not carry the gazer gene. The hatchling's were either euthanized or given away to people who wanted testers. I offered these hatchlings for free and had very few people who wanted them.

I have yet to decide if I will test other non sunkissed animals in my collection but I am sure that the gazer gene is out there even in non sunkissed morphs.

I think people who payed a pretty penny for sunkissed morphs or hets will be sorely disappointed when they hatch a clutch with gazers. It remains to be seen if people will be honest about it or not and just sell the possible hets to unsuspecting customers. I have a lot of respect for Specialcorns for letting all their customers from previous years breeding know that they have possible hets and for letting people know through several forums that they produced gazers this year. I am sure it was devastating for them to produce such beautiful animals that were gazers.
 
Actually, according to Dr. Hurley's entire info about it... she DOES believe that it is a vestibular-type disorder. She sent out a histopath on a hatchling, which came back negative for pathogens. That's an examination of cells, not a microscopic examination of the entire structure of the brain and/or skull. Equally, damage to the cranial nerve that deals with acoustic functions in animals with ears... causes stargazing-type clinical signs.

As to whether they have a vestibular system... Yes. That's how they know "up" from "down".

http://www.ncbi.nlm.nih.gov/pubmed/3485883

http://www.ncbi.nlm.nih.gov/pubmed/6606996

http://deepblue.lib.umich.edu/bitstream/2027.42/49912/1/900650110_ftp.pdf

http://www3.interscience.wiley.com/journal/109676481/abstract?CRETRY=1&SRETRY=0
 

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As to whether they have a vestibular system... Yes. That's how they know "up" from "down".

Yep. All land vertebrates do. I ~think~ fish do too but I am not 100% sure. And it's how they tell left from right & how fast their head is moving toward the zombie mouse too.

Actually, the other problem is that many vestibular problems need functional testing rather than pathology. So how do you figure that out in a snake? It's easier in humans, you can ASK them. In quadrupeds you can watch them walk But I can't figure out how to do it in a snake!

You've made some good points. I never thought I would GET a SG for a pet, just that I wouldn't euthanize one for being one. I still don't know what I would do with a SG if I hatch one.
 
Megan, you win..

I do not believe it is a vestibular disease or that the gazer's are dizzy. Dr. Connie Hurley sent one of her gazer's for pathological exam and nothing was found. So whatever is wrong with these animals is not visible under pathological exam. This would suggest a metabolic abnormality.

I have a gazer female and I agree with Tim that she acts more like someone with a movement disorder but not really Parkinson's disease. I really do not think she is suffering. If she was I don't believe she would be as good an eater as she is. She produced a beautiful clutch for me last year and is set to live out her life here as a pet. Her offspring were all het gazer's and proved to a greater than 99% chance that my male sunkissed does not carry the gazer gene. The hatchling's were either euthanized or given away to people who wanted testers. I offered these hatchlings for free and had very few people who wanted them.

As to the above quote, I didn't think I pulled that out of my ass, and I did not think I misunderstood what Connie put out there a while ago, years before some people even considered getting a corn snake. Oddly enough it behaves exactly like a simple recessive gene.. Thank you for your support Joanna.. I am glad you know first hand how these animals behave, without trying to site a riot act just to make a point..
 
I'm not citing a riot act... I'm trying to pull in scientific information as well as the current top of the differential diagnoses list. Not know up or down would create "dizzy" in a mammal at least. Would it create disorientation in a snake? Probably. We tend to call this disorientation "dizzy" and if you move slowly it isn't as aggravated. Do vestibular problems manifest with movement difficulties? Absolutely. If the issue is centered around CNVIII, a recessive trait (demyelination? atrophy? other physiologic abnormalities?) could indeed affect the snake in a fashion after what we see.

To provide more of Connie's information:

"BACKGROUND INFO

The word "stargazing" itself is a general term that indicates a neurologic problem in animals in which the animal has a tendency to hold the head back, "gazing at the stars". This symptom indicates dorsoflexion (head thrown back) and fixed staring up at rest. This symptom across the animal kingdom can be seen for a variety of reasons including neurologic conditions as well as anatomic abnormalities or pain. Causes of neurologic abnormalities leading to stargazing are varied, including:

* Toxin Exposure (no pest strips and insecticides most common with snakes)
* Heat or Cold Stress
* Viral Disease (Boids with inclusion body disease (IBD) - retroviral cause)
(link to more info: http://www.merckvetmanual.com/mvm/in.../bc/171413.htm)
* Bacterial Disease (bacterial meningitis, etc.)
* Trauma (crushing while closing the cage, falling cage furniture, etc.)
* Congenital abnormalities (hydrocephalus, kinked neck, others)
* Tumor of the skull/brain
* Respiratory Disease in Snakes - will often sit with head held in abnormal positions when struggling against an URI
* Heritable Disease in the Corn Snake - unknown mechanism at this time


When discussing what we think of as THE stargazing in corns, what we are referring to is a heritable condition that actually appears to be an abnormal vestibular system (balance system) leading to animals that have difficulty knowing which way is up, especially when they lose visual landmarks (like when picked up) or when they are excited.

Perhaps more appropriately termed "Heritable Vestibular Syndrome in the Corn Snake", stargazing in this sense refers to a very specific condition we have been researching for the past several years.

CLINICAL SIGNS

* Condition present at hatch
* Condition does not worsen over time (may appear to improve as the snake learns to adapt with age)
* More noticeable when the snake is agitated/excited
* Appear normal at rest (though may assume bizarre positions at times)
* Will weave the head back and forth, sometimes rolling the head back or to the side
* When fleeing, may crawl upside down or flip between back to stomach
* Often will sit with head raised up or flipped over backwards
* Hugs the hand tight, crawling backwards to stabilize itself when unbalanced/picked up
* Unpredicatable crawling, especially when agitated, uncoordinated
* Eats, Drinks, Sheds, Grows, Breeds, Lays Eggs Normally (other than the above mentioned signs)
* Has never been shown to be contagious, even with co-habbed snakes or siblings
* Other than imbalance, does not impact the quality of the snake's life, does not affect cognitive ability, and the snakes display the same emotions as normal snakes with no sign of added stress due to the condition (i.e. they don't appear to suffer from the condition)


What we have tested so far:

* A full pathologic evaluation was done on a sacrificed hatchling stargazing corn snake to determine if there is an anatomic cause for the condition or any signs of viral disease (inclusion bodies in cells typical of viral infection). The histopathologic results were detailed and normal. No cause for the condition was seen at a microscopic level.


Tests recommended to be completed in the future

* Full blood screen to rule out certain metabolic causes.
* Histopathologic analysis on an adult stargazer to give the pathologist a larger specimen to examine to see if subtle anatomic defects are present that weren't seen in the hatchling.
* A CSF analysis would be helpful, though technically challenging to collect.

The above 3 things could be performed on a single adult animal that was humanely euthanized. We have plans for this in the future with an adult gazer at some point.
"


If you would like, I could even show the videos of gazer hatchlings/adults to my local reptile vet and see what he says.
 
*shrugs*

If you would like, I could even show the videos of gazer hatchlings/adults to my local reptile vet and see what he says.

Do what ever you feel you must do.

Your absolutely correct.. 100% correct.. Your point was made..
 
The pathology report essentially rules out demylelination and atrophy. Those should have been pretty easy to see even on a hatchling.

I did not remember that Connie thought that it was a vestibular problem. I still think they look like they have a movement disorder. They don't seem to have an issue being upside down and are not fighting to right themselves when they are upside down and in fact can stay that way calmly for a while.

To be honest I do not think that snakes often feel distress. I have seen severely injured and ill snakes that do not look like they are suffering. The only time I have seen a distressed snake is when they have accidentally caught a tail or head while trying to close a bin. It is clear then that they are suffereing because of the flailing. I really don't think it is cruel to keep these snakes alive but I really only advocate doing so for educational purposes including testing for the gazer gene.
 
The pathology report essentially rules out demylelination and atrophy. Those should have been pretty easy to see even on a hatchling.

It might depend upon which samples were sent in. Was it just the brain, and leaving behind the nerve after it exited? Or was is the entire head? I'll have to ask her tonight. Maybe see if I can get a copy of the histopath report. That sort of stuff fascinated me anyway.
 
a bit off topic but I actually had a snake which was exposed to toxins and had the same symptoms as "Stargazers". I got him at a pet store for free because he couldn't eat live mice and was "unsellable". After a year he completely recovered from all his symptoms. yay :D
 
Connie sent in a 1 1/2 month old female snake. The whole snake was evaluated. The whole path report is on Connie's forum.
 
I did not remember that Connie thought that it was a vestibular problem. I still think they look like they have a movement disorder. They don't seem to have an issue being upside down and are not fighting to right themselves when they are upside down and in fact can stay that way calmly for a while.

Exactly, but what do I know as an uneducated tard ???

Regards.. Tim of T and J
 
Exactly, but what do I know as an uneducated tard ???

Regards.. Tim of T and J


You are a highly educated. I know this. However, you said she didn't think that... and I quoted where it says she *does*.
 
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