I will still keep a few harems of my regular mice, but if all goes well with the swiss websters, I will replace all my harems eventually. Nice thing is, my harems are unrelated, so I am able to make up new harems from them and never have to worry about inbreeding. I've had success with putting together new harems with my regular stock, picking from harems that are good producers and good temperment. I've heard some people say negative things, such as they are more prone to disease because they are lab mice bred in sterile environments, which I suppose would be true if they came from a medical/laboratory supplier. But mine came from stock that has been long removed from the "lab suplliers", and have a good track record as excellent producers. I'll be keeping tighter breeding records on these two harems, as I would like to keep a pure strain always, and even perhaps start selling a few harems.